Dr. Jila Maki, MD, Specialist in General Medicine, Datteln, Germany
“Autoimmune diseases and autoimmune disorders are umbrella terms in medicine for diseases with reactions of the body that are based on a disturbed tolerance of the immune system to the body’s own substances and which lead to the formation of antibodies. In the broadest sense, immune reactions against the microbiome, i.e. attacks on the microorganisms belonging to the body, are also classified as autoimmune diseases. Autoimmune reactions are often similar to immune reactions against pathogens.
Furthermore, immune complexes or receptor activating or blocking antibodies can lead to symptomatic disease. In western countries about five percent of the population is affected by an autoimmune disease. Many autoimmune diseases are poorly understood and cannot be treated causally; they often persist for life and can be treated with anti-inflammatory or immunosuppressive drugs~” (Wikipedia 2019)
Studies show that the number of autoimmune diseases is rising. The clinical picture can take different forms and have different organs of attack. It is estimated that 4 million people in Germany suffer from a known autoimmune disease and are treated accordingly. Unreported and undocumented cases have not been taken into account in these statistics.
But what are autoimmune diseases? Why are so many people now affected by them? What happens in the body in the case of an autoimmune disease? What are the prerequisites for contracting an autoimmune disease?
What diagnostic or therapeutic options are available to us to detect and cure these diseases? Are there chances of recovery? All these questions are part of my presentation today. I will use a case study to describe the process of the disease in detail and present therapies and treatment methods.
A 54-year-old male patient comes to my practice on 04/03/2019 because he has been suffering from regular and sometimes unpredictable diarrhoea for months.
A colonoscopy in January 2019 revealed no clinical findings. A stool analysis conducted by his GP also showed no abnormalities. The patient has been diagnosed with persistent leukopenia and thrombocytopenia of varying intensity since 2001.
The patient’s symptoms were multiple haematomas with no previous trauma, susceptibility to infection and general exhaustion. A bone marrow biopsy at the time gave no indication of malignant haematological systemic diseases. However, a sonographic examination indicated splenomegaly (enlargement of the spleen) of an average length of 20 cm.
The patient was treated with glucocorticoids (prednisolone) from 2001 to 2011. Brief discontinuation of the medication resulted in recurrence, resulting in the patient having to continue the therapy again. The disease was re-evaluated in February 2017. Here, trials with prednisolone, eltrombopag, octabam were unsuccessful.
Rituximab (Mabthera) was therefore administered over a period of 4 weeks in February and March 2017. After treatment with rituximab, there was a weakening of the immune system and, as a result, circulatory dysregulation, severe and foul-smelling diarrhoea and herpes on two occasions (once in the eye). Further examinations revealed the presence of helicobacter pylori both in serum and stool, which was treated with antibiotics.
In March 2017, the patient developed severe pain in the lumbar region and chills during the night. Further examinations resulted in the diagnosis spondylodiscitis, a consequence of the methicillin-sensitive staphylococcus aureus. Antibiotics were administered (flucloxacillin and ciprofloxacin) over a period of three months. Surgical intervention was not considered because of the improvement in pain symptoms.
In April 2017 he was admitted to hospital due to a febrile infection, a current CT diagnosis confirmed increasing splenomegaly and newly occurring abdominal lymphadenopathy. The patient was again treated with prednisolone 100 mg since all other immunosuppressive drugs had so far failed to provide stability of the condition.
The discharge report of May 2018 described a stable and good overall condition. According to the patient, however, the malodorous and severe diarrhoea and the state of exhaustion did not improve. The patient had a history of frequent tonsillitis and otitis media in childhood and later revealed allergic reactions to pollen.
On admission: a patient of normal weight with distinctly pale skin and mucosal colouration. The physical examination revealed diffuse and purulent pustules on the chest and on the inner side of the thighs. Foetor ex ore.
Ultrasound examination of the abdomen
The liver exhibits a distinct hepatic steatosis with an echogenic image, with impedance jump to the right kidney and with inhomogeneous structures. Distinct hepatomegaly, the gall bladder shows clear evidence of multiple stones in both transverse and longitudinal sectional views. Likewise, the formation of sludge. Gall bladder wall is enlarged and irregular.
Extrahepatic bile ducts are free of stones, but they show a shift in size. Pancreatic head detectable after multiple focusing, discrete pancreatic lipomatosis. Spleen shows distinct splenomegaly with a longitudinal section of 17 to 18 cm and width of 9.8 cm.
Intestine shows a strong meteorism in all planes, especially in the left flexure, where the intestinal wall is enlarged and clear intestinal reliefs are detectable, which suggests an increased accumulation of gas; discrete accumulation of fluid outside the intestine also suggests a chronic inflammatory process. Prostate is slightly enlarged. Paraaortic lymph nodes show discrete enlargements, as confirmed by the CT findings of 2018.
Interpretation of laboratory results
The laboratory diagnostic examination shows first and foremost pancytopenia. Here, the number of leukocytes as well as erythrocytes and thrombocytes are reduced despite the intake of corticoids. Ultrasensitive or highly sensitive C-reactive protein is an objective laboratory diagnostic criterion for detecting an interleukin-induced inflammatory reaction, which is significantly increased. Increased CRP levels are a common concomitant of autoimmune diseases, although it is assumed that this score is more likely to indicate an inflammatory process.
Reduced concentration of alpha-lipoic acid indicates a chronic inflammatory process and increased consumption of this substance. It is also an indication of oxidative processes within the cell membranes as well as an indication of reduced absorption in the intestine. In addition, a lack of some important micronutrients and vitamins such as selenium, potassium, magnesium, vitamin B6, vitamin D, coenzyme Q10 can also be observed. Glutathione deficiency: total levels and the reduced form indicate oxidative and proinflammatory processes.
On the other hand, increased lipid peroxidation in plasma indicates a peroxidation process of membrane lipids and all other lipid-containing cell structures. DNA oxidation indicates oxidative processes, with damage to the bases of nucleic acid, in this case, guanine. As a result of such processes, guanine is converted into 8-hydroxyguanosine, which would normally have to be eliminated by DNA repair enzymes. Accumulation of 8-hydroxyguanosine occurs when repair enzymes are deficient or overstressed.
This accumulation can then lead to genetic changes, mutations and, as a result, to severe diseases. Lactate-pyruvate tests indicate disruptions in the energy metabolism or disruption of the mitochondrial respiratory chain. This may be the result of liver diseases, heavy metal intoxication, environmental toxins as well as chronic inflammatory processes. Finally, a clear hormonal disorder with a sometimes massive hormone deficiency as well as neurotransmitter serotonin deficiency confirm the patient’s condition with chronic exhaustion syndrome, listlessness and increasing concentration disorders.
Interpretation of the stool analysis
A large number of different types of microbiomes ensure a stable, physiological intestinal environment and hence better absorption of nutrients, formation of vitamins (including vitamins B1, B2, B6, B12 and vitamin K, antimicrobial substances) and a better protective mechanism against the body’s own toxins, foreign contaminants and environmental toxins. They control essential metabolic processes by providing energy sources or releasing immunomodulating substances. It is possible to gain an overview of these microbiomes and their relationships with the help of molecular genetic stool analysis.
When evaluating the stool analysis of the patient, it becomes immediately apparent that the intestinal microflora is damaged. Diversity (the range of species) is reduced. A massive (no longer measurable) elevated calprotectin level of more than 800 mg/l indicates the presence of a chronic inflammatory process, which may be partially accompanied by damage and necrotic changes in the mucous membranes.
This correlates with a reduced activity level of secretory immunoglobulin A, which neutralises antigenic substances and prevents the adhesion of pathogenic bacteria, viruses and fungi to the surface receptors on the intestinal mucosa.
The presence of pathogenic germs such as clostridia strains (in this case clostridium cluster I) indicates an increased production of toxic substances, which damages intestinal epithelia and thus promotes the occurrence of cell atypes. Significantly reduced germ counts of butyrate formers such as gram-positive bacteria and faecalibacterium prausznitzii indicate insufficient energy supply for the colonocytes and thus poor integrity of the mucosal barrier and increased risk of leaky-gut syndrome. Increased secretion of histamine in stool indicates allergy and a predisposition to food intolerance.
Urine examination after one-time chelation therapy
Interpretation of urine diagnosis after single administration of chelation treatment
This urine examination with low excretion of heavy metals indicates that this patient does not have a good excretion capacity and that treatments such as chelation therapy are not an option at the beginning. Repeated administration of chelate complexes can lead to kidney damage and damage to the remaining liver cells.
Autoimmune disease treatment and therapy methods
It is possible to establish on the basis of detailed investigations that this clinical picture is a chronic multisystemic disease. They are disruptions to the regulatory circuit between the immune system, nervous system and endocrine system in combination with the disruption to the metabolic system. A comprehensive but fine-tuned therapy is therefore called for.
The patient was treated by us with BICOM® bioresonance therapy, with the blockages (including scars and radio radiation) being considered at the beginning. Further blockages include heavy metals, environmental toxins and dental blockages, the removal of which should be well-considered in such a case and, if necessary, accompanied by infusions for better elimination. We use programmes 900 and 910 for scar blockage. It is advisable to perform tissue blockage with 951 and 927 and energy blockage with programmes 915 and 918.
If mental blockages are involved, channel 2 can include the essential oils or Bach flower ampoules, depending on the test. Onetime chelate therapy at the beginning and poor elimination of heavy metals indicated that it would be better to postpone the timing of detoxification treatment with chelate complexes to a later date.
Intestinal restoration using bioresonance therapy was carried out repeatedly over several weeks. In view of the serious disturbance of the intestinal microflora, mycosis therapy with CTT ampoules was first carried out here using programmes 191 and 192 for elimination. The programmes Improve intestinal flora, Regulate intestinal activity and Improve intestinal activity with programmes 930, 565 and 561 were also used.
Both bacteria and viruses were eliminated because dysbiosis was detected. Ampoules of CTT were used after the test. The programmes for this are 191 or, in the case of elimination, 192. As a dietary measure, the patient had to avoid certain allergens such as cow’s milk, wheat, sugar, yeast and a number of other foods.
Substances such as bitter substances, natural prebiotic substances and substances for elimination and detoxification (such as 3 drops of lymphdiaral base drops, quassia similiaplex and juniperus similiaplex) were administered to improve elimination and strengthening of the intestine and stability of the acid-base balance. A mild and very effective substance is the combination of myrrh, coffee charcoal and camomile (MYRRHINIL-INTEST). General detoxification with programmes 930, 430, 480, 970 was used from the very beginning until today to support the organs.
Here it is important to remember that the dose and administration of substances must always be tested and verified bioenergetically in advance. As the organs of elimination such as the intestine, liver and lymph are clearly stressed in this case, micronutrients and substances were administered at the beginning for the purpose of parenteral detoxification.
The patient was first given vitamin D in liquid form due to a severe vitamin D deficiency and due to the countless studies and findings that vitamin D deficiency promotes the occurrence of an autoimmune disease. The liquid form means that the absorption of the substance is more likely to be assured in cases of known liver disease and poor gastrointestinal function. Vitamin dose at the beginning was 5,000 to 6,000 lU/day; the dose was later increased to 10,000 IU/day.
Steroidal hormones (in this case in known hepatic steatosis first progesterone, later DHEA and testosterone as epidermal form) were also administered. This largely avoids liver circulation. All these measures were taken with homeopathic complex remedies in parenteral form for the purpose of detoxification. In this case, 250 ml of NaCl solution were used with 1 – 2 ampoules of Nux Vomica Injeel, 1 – 2 ampoules of Solidigo Comp, 1 – 2 ampoules of Hepar Comp and 1 – 2 ampoules of Lymphomyosot N and Cholo 2.
Later on, infusions to stabilise the acid-base balance such as sodium hydrogen carbonate and lactic acid ampoules were administered depending on the test. Phosphatidylcholine was first administered in parenteral form and later orally in order to stabilise the cell membranes. Phosphatidylcholine and its metabolites such as lysolezithine and multiple unsaturated fatty acids such as AA and EPA are important membrane components. They are essential for maintaining the functionality of cells and cell membranes.
BICOM® therapy was the main therapy in all phases of the treatment and an essential accompaniment to the other forms of treatment. After only a few weeks (following multiple mycosis therapies as well as elimination of the pathogens through the bioresonance method), the patient developed severe skin mycosis in the area of the mouth and anus as well as the genitals, and was therefore continuously better from that point on.
I always inform my patients that the onset of a rash or worsening of the original illness is possible. The patient is still undergoing treatment and is being treated with bioresonance therapy, among other things.
Laboratory tests 5 months after the start of treatment
This laboratory report shows that the number of thrombocytes has stabilised. The patient has never experienced normal numbers for this under various immunosuppressive drugs since 2001, and leukopenia, at 2.8, has also been regularised. The number of erythrocytes has improved only slightly.
Stool control during therapy
Here you can see that calprotectin (as a reliable indicator of chronic inflammatory processes) has been reduced from an unbelievable level of over 800 mg/l to 106.47 mg/l. I quite often initiate the occasional laboratory check for navigational purposes with such serious diseases. The improvement in patients’ symptoms is often not sufficient to assess and take further steps.
The patient feels significantly better with a correlation with the improvement of the laboratory chemical tests. He has had a stable gut for weeks and no more diarrhoea. Fatigue and exhaustion have largely improved. There are certainly more therapy sessions ahead of us, but these laboratory tests indicate that the path is the right one.
Epidemiological studies indicate that autoimmune diseases have been increasing in number and variety in recent years. There are 4 million known and registered patients with autoimmune diseases in Germany alone. The causes are not only genetic, but rather epigenetic factors. They include the effects of pollutants and contamination of the air, water and ultimately our food.
Stressors using the example of complex substances such as chemicals, inhalants, plastics, heavy metals, pharmaceuticals, chemotherapeutics, radio and radiation exposure and, above all, increasing time pressure and stress in everyday life, lead to changes and blockages in the essential enzymes of the detoxification system, and thus to heavy stress in phase I and phase II detoxification.
As a result, the body is under the constant influence of toxic substances and the development of multisystem diseases. They are disruptions to the regulatory circuit between the immune system, nervous system and endocrine system in combination with the disruption to the metabolic system. Continuous and discrete detoxification management under bioresonance therapy, accompanied by the administration of coenzymes and other natural substances such as bitter substances, and prebiotics to regenerate the detoxification system, can completely reverse such clinical pictures (if possible in an early phase).
In order to prevent detoxification measures from working in the opposite direction and leading to poisoning, hydrophilic substances should be removed first and later lipophilic substances should be removed by adding chelate complexes. This is why it is important to understand the mechanism of poisoning and detoxification and to apply therapies in practice with the necessary sensitivity.
A serious and complication-free accompaniment for such intoxication and severe blockages of the most important detoxification mechanisms is bioresonance therapy, which can be used without risk from the very beginning of treatment.