Hemopyrrollactamuria (HPU) a common metabolic disorder with far-reaching effects

Silke Nunner, Naturopath

Patients often come to our practices with so many health problems that we, as therapists, struggle to know where best to start treatment. They not only present with multiple allergies and food intolerances but also exhaustion, weakness, thyroid problems, infections and adverse effects from numerous chemicals and synthetic products. Women with menstrual problems or who are unable to conceive also often find their way to us.

Despite comprehensive therapy, treatment is unable to make definite progress and patients continue to feel their resilience is below par. And this despite the fact they have a healthy diet and lifestyle.

When I looked into HPU more closely, I was able to establish this metabolic disorder as one of the underlying causes in this area.

The extensive range of symptoms displayed to widely varying degrees is probably attributable to the difference in individual people’s metabolisms. As almost my entire family is affected by this metabolic disorder and many people in my practice also tested positive for HPU, shedding light on this problem is an issue very close to my heart.

  1. What is haemopyrrollactamuria (HPU)?

HPU involves an impairment of the haem synthesis process or, to be more precise,

of the structure of haem. Of the 8 enzymes, 3 or 4 are reduced in quantity. As a result a newly formed structure, the haemopyrrollactam complex, is excreted via the urine as a waste product of haem. This HPL complex arises through a minor genetic defect in the enzymes of haem synthesis or, to be more specific, in uroporphyrinogen III cosynthase and uroporhyrinogen decarboxylase. As a result, more coproporphyrinogen I is produced, leading to haem developing a new inverse ring structure which has only limited functioning however.

The organism tries to get rid of this defective molecule. The vital substances zinc, manganese and vitamin B6 are bound to the faulty haem making it water-soluble. It is then excreted via the kidneys. In addition the production of P5P (pyridoxal

5-phosphate), the active form of vitamin B6, is affected by the zinc deficiency, as zinc is required to convert the non-active form pyridoxin into P5P.

The body is then only able to metabolise vitamin B6 in its active form P5P which is not supplied through food however. Deficiency develops over many years which is often only evident when the immune system is weakened further. Finally the body is no longer able to compensate and becomes exhausted and unwell as a result. Moreover HPU is stress-induced, in other words, more of the toxic HPL complex is produced due to stress.

Vitamin B6 is normally taken up through the enterocytes of the intestinal mucous membrane. Once absorbed in the liver the chemical reaction known as phosphorylation takes place in the hepatocytes (liver cells) and the metabolically active form pyridoxal 5-phosphate (P5P) is produced. In “healthy” individuals, excess pyrroles are excreted in bile pigments through the stools (NB: bile pigments are made up of pyrrole rings).

If adequately supplied with vitamin B6, the body holds about 100 mg in total, mainly in the form of pyridoxal 5-phosphate. This is distributed over the muscles and liver.

It is easy to imagine how, with insufficient B6 and the associated loss of vital substances, a number of symptoms would appear.

It is assumed that vitamin D is also affected by impaired haem synthesis. The same applies to chromium (III). It is also probably reduced in the same way, i.e. it attaches itself to the pyrroles and is then excreted in the urine.

Development of HPU

  • Congenital HPU

HPU is mainly inherited through the female side of the family and consequently the ratio of affected women/men is 9 : 1. Dr Kamsteeg, the leading researcher in the field of pyrroluria, thinks that 1 in 3 women may be affected. I can confirm this if I consider the cases in my practice. Probably because we bioresonance therapists have so many allergy patients who are often affected by HPU. Exhaustion is also an issue in our modern world. Moreover HPU patients are particularly fragile due to stress. Instances of this have risen dramatically in recent years due to the rapid changes in our lives. When patients present with Epstein Barr virus or multiple viral and bacterial conditions, they are frequently trapped in a state of exhaustion in my experience.

It then often emerges that the patient’s energy levels have been low for a long time and they have suffered frequent infections. Not infrequently there is a precise point in time from which a marked deterioration occurred.

The congenital form of HPU cannot generally be cured, however significant improvements can be brought about by targeted life-long consumption of certain micronutrients (the treatment is described later). The existing stresses can be treated admirably with the BICOM device, as we all know.

  • Acquired HPU — nitric oxide (NO) disruption

Nitric oxide is a gas which can be produced by all the body’s cells. Its function is to enable arteries and bronchial tubes to dilate and relax after tensing. It is also involved in blood clotting and nerve growth.

Furthermore it has a signalling function for many cells and, as part of the immune system, destroys bacteria, viruses and fungi.

Disruption of the nitric oxide balance as a result of accidents, trauma, injuries to the cervical spine, surgery (positioning) etc. leads to irritation of the sensitive nerve tissue of the cervical spine and this in turn results in excess NO in the mitochondria. These regulate oxygen content in the cells and so haem synthesis may be impaired as a result.

NO levels in the body are also raised in cases of prolonged inflammation.

The acquired form of HPU is becoming increasingly common and can usually be cured. I have had positive experience here with bioresonance therapy and supplementing the deficient nutrients.

Function of haem: (To help understand the major impact)

Haems are protein components of the blood pigment haemoglobin. Haem consists of a ring structure, the pyrroles and a central iron atom.

Haem proteins are produced in the membranes of the mitochondria. Haem synthesis takes place in the mitochondrial inner membrane and requires iron, vitamins B2 and B6, zinc and the amino acid glycine (an acid from the citric acid cycle). If this process is disrupted, haem functioning is restricted to a varying degree and consequently the mitochondria are damaged with multiple implications for the metabolism.

Haem proteins are required in various metabolic processes. Here is a rough overview:

  • Detoxication synthesis
  • Energy production
  • Production of hormones
  • Storage of D3
  • Muscle function (myoglobin)
  • Haem metabolism in the mitochondria also stabilises glycine, chromium and taurine
  • Melatonin production requires haem

Symptoms of haemopyrrollactamuria resulting directly from deficiency in pyridoxal 5-phosphate, zinc and manganese

  • Myasthenia, reduced muscle build-up, muscle spasms, paraesthesia, seizures: as haem is the basic building block of muscle protein.
  • Myalgia/rheumatism: because pyruvate dehydrogenase occurs in the mitochondria, pyruvate accumulates in the blood and degrades to lactic acid which can be measured in the urine and blood. (Glucose becomes pyruvate and the degradation of pyruvate is referred to as dehydrogenase)
  • Facial pallor: because haem is required to produce melatonin. Sleep disturbance can also result from too little melatonin.
  • Vitamin D deficiency: Cytochrome P450 is required to store vitamin D. Despite large doses of Vitamin D it is not possible to replenish the storage capacity of patients with HPU. Osteoporosis and arthrosis may be a consequence of deficiency. Vitamin D also activates the white blood cells in cases of infection and stimulates muscle cell growth.
  • Thyroid problems: The thyroid gland needs cytochrome P450 for thyroperoxidase
    (TPO) and so Hashimoto’s thyroiditis and even PCO may result from HPU. The authors in my research assume that antibodies are produced if the enzyme is incorrectly structured and the body sees this as defective.

The TSH level is always below 2 IUNI in HPU patients. If it is below 1, diminished fertility must be considered.

  • Catecholamines (adrenalin, noradrenalin and dopamine): are blocked in the event of nitrosative stress amongst other factors and the conversion of tryptophan into serotonin is impeded. In addition, as a neurotransmitter, histamine regulates adrenalin excretion in the adrenal medulla.
  • Dopamine deficiency: as a result of P5P deficiency, leading to mental health
  • Exhaustion, tiredness, burnout, fatigue: HPU is induced by stress. If stress increases, more energy is required and more pyrroles are excreted. Consequently burnt out patients should first be stabilised and then HPU considered.
  • Allergies: reduced IGA due to manganese deficiency. Histamine levels are then low due to zinc deficiency and the resulting surfeit of copper accelerates histamine breakdown further.
  • Headaches and migraines: are the result of low histamine levels.

An external sign of histamine intolerance is a long second toe.

  • Detoxication: is disrupted, cytochrome P450 is required here. Medicinal products affect HPU patients differently as they are not broken down properly. If taken for a prolonged period, high concentrations of medication lead to liver induction (intensification of the 1st detoxication phase in the liver). The effective part of the medication is lost as a result and the metabolites remain in the body. The 2nd detoxication phase does not function properly due to the lack of glutathione (activates and breaks down insulin). The side effects of the medication are then intensified (porphyrinogenic drugs).

B6 deficiency

  • Homocysteine: is often at high levels due to B6 deficiency which can lead to or encourage vascular problems g. arteriosclerosis.
  • Histamine deficiency (histapenia): DA0 needs B6 to be activated. Foods containing histamine trigger an allergic reaction if DAO is deficient. Patients also manifest slight bruising as well as ulcers, strongly pigmented skin, tinnitus, sensitivity to anaesthetics (in conjunction with low B12 levels).

Another supposition is that, when histamine levels increase in the CNS, serotonin and/or dopamine are suppressed. The result: anxiety, tension, panic, depression, sleep disturbance.

  • Anaemia: due to disrupted haem biosynthesis.
  • Degeneration of the peripheral nerves and afferent ataxia: this means the body can no longer pass on to the brain the necessary signals which are important for
  • Progesterone deficiency: B6 and zinc are required for the production of Progesterone levels are often very low in women suffering from morning sickness. Dr Kamsteeg found elevated levels of HCG in HPU-positive women during pregnancy. Nausea often lasted up to 5 months in these women.

Zinc deficiency

  • White spots on the nails are an external indication of zinc deficiency. Poor eyesight at twilight, hair loss, immunodeficiency, neurasthenia, anaemia, fertility problems and impaired wound healing may also occur. As well as tiredness and problems concentrating.
  • Stomach/intestines: protein inadequately digested due to zinc and manganese Peptidases (protein-cleaving enzymes), which break down fish or meat into amino acids, are reduced.

Diamine oxidase (DAO) needs B6 in order to be broken down. Foods containing histamine then trigger an allergic reaction.

  • Carbohydrates: are poorly digested. Dr Kamsteeg discovered irritable bowel or spastic colon in 64 % of patients. 30 % of HPU sufferers consequently complain of discomfort in the upper abdomen. This may be the result of increased pyruvate and therefore lactate formation. It leads to flatulence and/or heartburn. Carbohydrates reinforce lactate formation and, as a result, patients may suffer pain in the joints and ligaments in the mornings and also swelling in the joints in the middle of the fingers.
  • Type II diabetes: if there is a chromium deficiency here then it can be assumed that zinc and manganese levels are also reduced. Manganese and zinc are antagonists of copper. Raised copper levels may arise.
  • Fructose intolerance: the liver converts fructose into glucose. This requires the enzyme adolase B which, in turn, depends on zinc.

A tendency to hypoglycaemia if the individual does not eat at frequent intervals is a sign of this. Symptoms such as trembling, dizziness, nausea, mushy stool, itching, nightmares, problems sleeping, sweating, urinating frequently and general debility are the result.

  • GLUT 5 which is activated by thyroid hormones and glucose is responsible for the absorption of fructose in the intestines. Virtually everyone with fructose intolerance display signs of depression in old age.

Manganese deficiency

  • Joint problems, hypermobility, pelvic instability:

Manganese is needed to build up cartilage. Reduced cartilage formation frequently

leads to hypermobility in the joints and ligaments. Problems also develop in the knees and pelvis due to this deficiency.

  • Connective tissue problems such as varicose veins, slipped disc, arthrosis, meniscal injuries with no trauma.
  • Impaired detoxication: resulting in alcohol intolerance, heavy metal contamination, toxic overload. Part of the process of breaking down toxic urea takes place in the mitochondria. ATP is consumed in this process and manganese must be present as a co-factor for it to work.
  • Manganese deficiency leads to tiredness.

Difference between HPU/KPU and resulting mitochondropathy

Kryptopyrroluria belongs to the porphyria group, metabolic diseases accompanied by disrupted synthesis of the red blood pigment haem and associated with the clinical picture of schizophrenia, according to ICD-10. The view of the symptoms was initially limited to mental illness as it was rather a chance discovery by two American psychiatrists while conducting neurological research. The pyrroles were stained and thus made visible in the urine. The name “mauve factor disease” or malvaria arose due to the purple colour. The patients in whom pyrroles were found all suffered from mental illness and therefore the symptoms found were restricted to this area.

It was not until the year 2000 that the Dutch physician Dr John Kamsteeg carried out further research on pyrroluria and found additional pyrroles. Dr Kamsteeg coined the term haemopyrollactamuria. This has so far not been included in the ICD-10 Classification.

With KPU too, haem synthesis is disrupted. However here the problem lies not with building up haem but with breaking it down. Enzymes are lost here too which may be responsible for consequential mitochondropathy and can therefore have similar effects to those of HPU. Both conditions result in loss of micronutrients. Detoxication is disrupted and there is evidence of vitamin D deficiency. The symptoms can usually be improved however by consistently supplementing the vitamins required.

It is important that the HPU test is conducted with a 24-hour urine test carried out by the Dutch-based laboratory KEAC Parkstad (Centre for Environmental Medicine). This is far more sensitive than the inexpensive KPU tests which are sometimes offered by German laboratories.

It is also important to understand what disruption in the mitochondria means for metabolism. When faced with the following familial diseases (especially in the mother), mitochondropathy should always be considered as this frequently occurs in such cases:

  • Migraine
  • Diabetes
  • Rheumatism
  • Allergies
  • Dementia
  • Alcohol intolerance (increasing with age)
  • Reduced physical and mental performance (forgetfulness, poor memory for names)

Testing HPU and supplementing nutrients

If HPU is suspected, patients can take an online test with KEAC. Their points total will give an indicative result. If the score is over 8, the urine should be tested. The necessary containers and documents for a 24-hour urine test which detects HPL complex are then ordered direct online. The patient then sends everything back direct to the Netherlands and also settles the firm’s fee themselves. The results are emailed to the therapist.

Peak pyrrol excretion occurs 2 — 3 hours after the individual has taken his/her hot meal.

Micronutrients must be eased in during the first 14 days. The body first has to get used to them slowly. If the patient is unable to tolerate them, however, it helps to start with P5P and taurine. Minerals should definitely always be taken after breakfast, otherwise patients may experience nausea. Treatment should be halted immediately if mental problems are aggravated.

The food supplement “Depyrrol” contains a combination of zinc (15 — 30 mg as orotate/gluconate/histidine), manganese (up to 5 mg/day) and P5P (up to 60 mg). It is then easy to test using a test set with the different nutrients which ones the patient actually requires. Good products are also available from Heidelberger Chlorella or there is KPU Formula from Biogena and Kryptopyrrosan from Neurolab. After starting nutrient supplementation it then takes roughly a further 4 months before HPL complex stops being excreted and a further 5 months before the body regenerates itself. A prerequisite however is that patients also make lifestyle changes as HPU is induced by stress.

The following food supplements may be required, but each patient should be tested individually:

  • Magnesium (possibly directly as Depyrrol Plus) up to 600 mg/day, depending on
    the symptoms, if possible though 3 x day before meals, on an empty stomach
  • Vitamin D must actually always be supplemented. Determine the level in the blood!
  • If patients do not tolerate carbohydrates well, they often need B1, in other words thiamine, and possibly alpha lipoic acid
  • In the case of diabetes with evidence of lactate acidosis and pyruvate blockage, prescribe 300 mg benfotiamine B1 daily
  • B12, slows down nitrosative stress, beneficial in combination with biotin (2.5 —5 mg) and folic acid (400 — 800 mg)
  • 100 mg 5 HTP (Griffonia) and melatonin (3 — 5 mg and higher, caution: available only on prescription) taken in the evening before bed for 6 months has proved effective in my practice for sleep problems and mental exhaustion. Taking the amino acids glycine (5 —10 mg) and glutamine (1— 2 mg) before bed is also possible
  • My patients frequently also take a B complex at midday (caution, it should not contain pyridoxine, only P5P) and/or copper-free multivitamins in the evening

Nutrition and lifestyle

  • A low-fructose diet low in carbohydrates (large numbers of carbohydrates lead to B1 deficiency, a shortage damages the blood-brain barrier). It is remarkable how often cereal products are not tolerated. One assumption here is that this occurs following zinc deficiency over many years; moreover large numbers of carbohydrates drain the chromium reserves
  • Spend 30 minutes each day moving around in the fresh air. Oxygen prevents NO bonding to the mitochondria
  • Stress reduction, develop strategies to avoid getting annoyed or angry
  • To prevent hypoglycaemia at night, it helps to have a snack before going to sleep and have a small piece of glucose by your bed in case you wake during the night
  • Six small meals are better than three large ones, to help maintain a constant energy balance
  • Foods containing manganese: oatmeal, hazelnuts
  • Foods containing zinc: seafood, meat, fish, soy meal, cheese
  • Foods containing B6: soybeans, salmon, sardines, walnuts, lentils, whole grain, chestnuts, avocado, millet
  • Be sparing with hard cheese, vinegar, salami, ketchup, cocoa and smoked foods, as histamine is present here in excessive quantities
  • Detoxication should be supported e.g. with alkaline baths, teas, zeolite, Chlorella and Spirulina
  • If possible do not fast, if so with vegetables and rice, no juice cleansing

Case studies from actual practice

1st example of acquired HPU and treatment with the BICOM device

Man aged 44, former professional sportsman, since knee surgery for multiple torn ligaments at age 24 had suffered from allergies and exhaustion and was no longer able to get near his earlier performance levels. Then followed a long phase of visits to the doctor and treatments. When he presented in my practice in early 2018 he was already the father of 2 sons and working in a managerial position. The children passed on frequent infections and there was hardly ever a time when he did not feel ill or exhausted.

First step was a “full bioresonance test”. For this I test all the ampoules in my test sets and all the programs and also substance complexes (referred to henceforth as SC) without connecting the patient. The test often results in suspected HPU if the connections point to connective tissue insufficiency, disrupted detoxication and exhaustion and adrenal and thyroid symptoms. Manganese, zinc and B6 from the substance complexes will also resonate.

The patient history showed that the man viewed the operation itself as a fundamental change in his state of health. My assumption therefore was that he had acquired HPU. A surfeit of nitric oxide can occur in the cell during surgery following overflexion of the cervical spine, thereby permanently affecting haem synthesis. This appeared to me to be logical in this case.

My full bioresonance test revealed:

Viruses: alphaherpes, gamma-herpes, togaviruses, flu pathogens Bacteria: Streptococci, Staphylococci, Enterococci

Fungi: mould, fungi mix 1

Allergic stress: house dust, wheat, duck feathers, horses, nuts, pesticides, cobalt, insecticides, general anaesthetic, electronic smog

Inhalation: hazel, birch, pine, fruit blossom

BICOM programs: adrenal gland weakness, thyroid, liver, kidneys, lymph, regulating detoxification, toxins etc., exhaustion and much more

Nutrients: iron deficiency, selenium deficiency, manganese, zinc, heavy metal contamination etc.

The urine test carried out at KEAC in the Netherlands revealed: The 24-hour urine test was unequivocally positive.

Blood analysis revealed:

TSH: 1.07, progesterone reduced, ASL raised, B6 increased to 30 (remains in place, cannot be metabolised)

The patient had already been taking selenium, Omega 3, MG etc. of his own accord for some time but had not really perceived any improvement.

The test results were discussed on 1 March but there was no time then to start treatment immediately.

My prescription on this day:

DH EA D4, 1×5

Thyreoidea D4, 1×5

Mutaflor 1×1

Adrenal Intercell 2×2 (contains P5P)

Phytocortal Steierl 3×40 drops

We began comprehensive treatment with the BICOM device,  14 sessions in all:

The first appointment on 20 March was changed because the man had an acute flu infection which needed treating first. He had a sick note from the doctor. I usually start this day with blocks or detoxication.

  1. Basic therapy 10135 + fortify seniors
  2. 0 (“opening” the cell has proven effective with viruses)
  3. 10325 Ai according to Mr Riffel’s method with Coxsackie + orthomyxoviruses and alpha-, gamma-herpes, flu pathogens, togaviruses + Engystol SC
  4. 0 Ai

Orthomyxo- and Coxsackie viruses which caused the flu symptoms had disappeared after this session. Greatly improved state of health

Second appointment, 3 days later, 23 March:

  1. 3036 detoxification + lymph SC
  2. Thyroid gland chakra + unstable thyreoidea SC
  3. Adrenal program sequence (Dr Rauch’s method) + exhaustion SC


The third appointment did not take place until 11 April:

  1. 10135 + fortify seniors SC
  2. 0 + lymph SC
  3. 10326, 2. Viruses on Di with alpha herpes, gamma-herpes, flu, togaviruses + CH2 Engystol

The fourth appointment on 16 April:

  1. Basic therapy 10135 + energetic fitmaker SC
  2. 1 + kidneys SC
  3. (own program, adrenal glands with Dr Rauch’s method) + adrenal weakness SC
  4. 10327 stabilising viruses

From this point patient took P5P, zinc, manganese and Omega 3, selenium. Single dose of Ignatia C1000 due to a long-standing emotional problem

The fifth appointment on 23 April:

  1. 10132 + CH2 energ. fitmaker
  2. Adrenal gland with Dr Rauch’s method + adrenal gland SC
  3. 0 nervous system + CH2 Echinacea D4
  4. 0 D100+ 40.0 D200 with the viruses + TC mucous accumulation

After these sessions he had no further problems of note with pollen. He was in a much better state of health and he went three weeks without a cold, the first time in about 2 years

The sixth appointment on 2 May:

  1. 10132 + CH2 energ. fitmaker
  2. 0 + toxin elimination
  3. Block adrenal gland/1st chakra: Dr Rauch’s method (Di, low deep frequency, 5.2 Hz, wobble = yes, ampl. sweep sym., Di = 11.0, sweep rate = 28 sec, therapy time = 7 min, input cup: blood; input: ball applicator in both hands, output: modulation mat, magnetic depth probe or PowerApplikator on chakra/gland)
  4. 10325 Ai bacteria, as tested + lymph
  5. 0 Ai bacteria

The seventh appointment on 9 May:

  1. 10130 (normal energy levels for the first time and not exhausted)
  2. 0 nervous system + stress SC
  3. 10326 Di bacteria

Acupuncture during treatment

The patient was extremely tired after this session

The eighth appointment, 15 May, the first wheat therapy

  1. 3 thyroid gland + unstable thyreoidea SC
  2. Adrenal glands with Dr Rauch’s method + adrenal glands SC
  3. 10325 Ai wheat + lymph SC
  4. 0

The ninth appointment on 4 June, another cancellation due to acute tonsillitis which he caught after a lengthy flight:

  1. 5 toxin elimination + toxin elimination SC
  2. 3 geopathy
  3. 10325 Streptococci + laryngitis SC
  4. 0 Di bacteria + lymph SC
  5. 0 with elimination ampoules for bacterial killer, toxins, M protein, strengthening immune system, 4 minutes

10th appointment on 7 June, marked improvement and we were able to continue treating wheat:

  1. 3 lymph + lymph SC
  2. Thymus chakra with Dr Rauch’s method + laryngitis SC
  3. 10326 wheat Di + intestinal flora improvement
  4. 0 Di wheat + intestinal support

11th appointment on 11 June

  1. 10132 + fortify seniors SC
  2. 3 + lymph SC
  3. 10327 stabilisation wheat + improving intestinal flora SC
  4. 1 + 951.4 infection resistance + increasing powers of resistance SC

Today’s prescription was for Solunat no. 3 and Wala Echinacea mouth and throat spray, Neurolab’s Kryptopyrrosan for treating HPU

12th appointment on 9 July:

  1. 10132 + fortify seniors SC
  2. 0 liver + Taraxacum
  3. 0 insecticides, pesticides, general anaesthetic und electronic smog, 4 minutes
  4. 5 toxin elimination

Acupuncture LI 4, ST 36, LU 1, triple warmer 7, KI 3 und paranasal sinuses

13th appointment on 13 July (another ENT infection, this time with Citrobacter)

  1. 10132 + fortify seniors SC
  2. 3 + lymph SC
  3. 10325 Citrobacter + frontal sinusitis, acute
  4. Strengthening immune system Ai, low deep frequency, 7.8 Hz, amp. sweep sym: Ai 23, sweep rate 27 sec, wobble: NO, interval: NO, 8 min; input cup blood, applicator on thymus)

14th appointment on 19 July, final session

  1. 0 lymph
  2. 10326 Citrobacter
  3. 2 thymus + increasing powers of resistance SC

He was a lot better after this. We spoke on the phone, initially every week, then once a month. Mr M now feels fit and resilient. He is much less exhausted and suffers fewer infections. He is now able to practice sport regularly once more.

We did not treat the allergies at all because he was doing so well. We decided to wait. After treatment many of the stresses no longer tested. Kryptopyrrosan was initially prescribed for 9 months.

Second case of congenital HPU

A., aged 17. Came to me in summer due to severe exhaustion and Borrelia infection contracted six months previously and acute glandular fever. Both receiving conventional medical treatment but without any appreciable improvement. She suffered severe joint pain from the Borrelia infection. She suffered multiple allergies and asthma during the grass flowering season. She also often experienced headaches and nausea. I had already successfully treated her 13-year-old sister for multiple allergies. While being treated however her sister was diagnosed with Hashimoto’s thyroiditis, a clear indication of familial HPU.

The mother herself also had huge problems with allergies and severe joint pain such that she was hardly able to do any sport. She was also exhausted and slept badly.

  1. had been really bad for 2 years. She had had a dancing accident and a severe block in her atlas after which she received physiotherapy for a long period. It was then the tiredness and exhaustion started and numerous infections including several hospital stays due to her numerous illnesses. Yet nobody was able to really help her. I suspected HPU yet, despite my urging, no tests were carried out at first. I also did not want to simply prescribe supplements beforehand as the mother was yet to be fully convinced about bioresonance and laboratory results are often necessary to win people over. However as A. was soon feeling better, at least as regards the glandular fever, she continued coming for therapy.

A.’s first HPU test was only weakly positive, so not a clear result.

The blood count from the Biovis lab was as follows (normal values in brackets):

Iron 459 (460-480 mg/I), zinc 6.2 (7.0-7.6 mg/I), chromium 0.3 (0.5-3.9) ug/I, folic acid  479 (4780-1210 mg/I) and coenzyme Q10 0.74 (0.88-1.43 mg/I) reduced and copper/zinc quotient at 0.71 (0.135-0.165) and manganese 16.2 (5-15 ug/l) raised.

Vitamin D3 at 73.80 nmol/l was at the limit (62.50-170), according to the lab however the BICOM optima®l range from the viewpoint of preventive medicine is over 750 ng/I

Thyroid hormones T3 and T4 in 24-hour urine: T4 100 pmol/24 hours (170-1700), in other words reduced and the T3/T4 ratio therefore much too high at 4.31 (0.6-1.0)

The mother then decided on a 24-hour urine test after all and A’s blood count was informative. It quite clearly confirmed HPU.

Treatment with BICOM® bioresonance

As A. came to me because of acute glandular fever we did not carry out many tests, but just tried to get a rough overview. This revealed the following:

5 elements: metal, skin, connective tissue, tendons, large intestine, lungs, chronic stress ampoules: YinYang, bacterial infection, viral infection, heavy metal contamination, intra-cellular tissue, lymph

Bacteria: Borrelia burgd.

Viruses: Coxsackie viruses, beta- and gammaherpesviruses

Allergies: Artemisia, grasses, early flowering plants, trees 1, house dust, moulds, citrus fruit, stone fruit, milk, lactose

Programs tested:

Detoxification: liver 3063.0, 430.2, 431.3, lymph 3066.0, 930.3, 830.3, toxins 970.5, 290.6, pancreas/spleen 429.0, intestine 561.0, 562.0

Intracellular elimination 3460.0

Immune system energetic status: 428.2, 900.1, 951.4, 580.2, 583.1 thymus chakra with Dr Rauch’s method

Joints: 3090.0/3091.0

Blocks: thyroid chakra according to Dr Rauch Di, low deep frequency, select BP, 2.5 Hz, wobble NO, amp. step-wise increase: Di 11, time per step: 28 sec., interval NO, 7 min), 581.1 spine, temporomandibular joint 3054.0, 530.2, 570.9, stress regulation 3017.0, 3084.0

Treatment followed, first with the viruses and Marcel Riffel’s programs. In cases like this I always perform basic therapy beforehand and open elimination channels or release blocks, depending on test results.

  1. was then given a prescription for acute glandular fever with Fortakehl D5 for 5 days 3×10 drops, Schlissler salt no. 4 D6 3×4 for 6 weeks, and Phytolacca C30 for 14 days 1×3 and the Epstein Barr nosode C200 1×3 globules.

We treated the glandular fever with the other viruses in this way over 4 sessions in all and then the Borrelia in the same way. Marcel Riffel’s programs for eliminating stresses proved very effective here. We treated the pollen in summer when she was badly affected. I find the 10317 program series achieves very good results here.

The Borrelia was harder to treat as the pain in the joints, which initially got better, then reappeared in October. So we tested the patient thoroughly each time and gave her follow-up treatment. When I had finished with the 3 programs (10325, 10326, 10327 + 3453.0 or 3454.0), I went through the individual parameters and potentiation each week.

We were able to improve the joint pain a few times at least for several days during this period using 3090.0/3091.0, but relief was not lasting.

The following program has proved very useful for post-testing the pathogens, as all the amplification steps can be tested individually:

Ai, no bandpass, amplification: 64, sweep time 300 sec, interval: NO, 60 min

Then, after starting, press 1 and test the individual amplification steps from 0.025 onwards by pressing the arrow key upwards. If somewhere still resonates, I let this steps run for 5 minutes. The patient holds the ball applicator and is just connected to the output, with the pathogen in the input cup.

I have also programmed the same program with Di, which I test in the same way.

Once the viruses were eliminated, at least A. felt robust enough to return to school for the new school year, something which previously she would have found near impossible.

Due to time considerations we continued therapy at 14-day intervals and her energetic state improved noticeably.

There are other cases which I could report on here. The topic is really fascinating and I hope I have aroused your interest. I very much hope that you too can incorporate HPU in your own practice when diagnosing and treating patients.

Thank you very much for your attention.


Dr Barbara Hendel, 3rd edition 2015, Das Magnesium Buch, Schltisselmineral fiir unsere Gesundheit, Magnesiummangel rechtzeitig erkennen [The magnesium book, key mineral for our health, identifying magnesium deficiency promptly], VAK Verlag Kirchzarten

Dr Bodo Kuklinski, Dr Anja Schemionek, 15th edition 2016, Schwachstelle Genick, Ursachen, Auswirkungen und erfolgreiche Therapie [Nape of the neck as a weak point, causes, effects and successful therapy], Aurum Verlag Bielefeld

Dr Bodo Kuklinski, Dr Anja Schemionek, 6th edition 2018, Mitochondrientherapie — die Alternative [Mitochondria! therapy – the alternative], Aurum Verlag Bielefeld

Dr Christina Schmidbauer (ed.), 2nd edition 2017, Mikronahrstoff-Coach, Das groge Biogena-Kompendium der Nahrstoffe, Indikationen/Wechselwirkungen [Micronutrient coach, the large Biogena compendium of nutrients, indications/interactions], Verlagshaus der Arzte

Dr J. Kamsteeg, 5th edition 2013, HPU und dann? Beschwerden und Erkrankungen infolge einer „Pyrrolurie” [HPU and then what? Symptoms and illnesses due to “pyrroluria”], KEAC Verlag Kerkrade, NL

Christian Dittrich Opitz, 2nd edition 2017, Mitochondrien, mehr Lebensenergie durch gesunde Zellkraftwerke [Mitochondria, increased vitality through healthy cellular powerhouses], Hans Nietsch Verlag

Dr Tina Maria Ritter, Dr Luitgard Baumeister-Jesch, 5th edition 2018, Stoffwechselstorung HPU, Fur Patienten und Therapeuten [HPU metabolic disorder, For patients and therapists], VAK Verlag Kirchzarten

Dr Tina Maria Ritter, 1st edition 2018, StoffwechselstOrung HPU, Wenn Stress krank macht. Das Selbsthilfe Programm [HPU metabolic disorder. When stress makes you ill. The self help programme]. Trias Verlag, Stuttgart

Kauffmann, Sascha, Kaufmann Kyra (2015) Stoffwechselstorung KPU/HPU, die 101 wichtigsten Fragen and Antworten [KPU/HPU metabolic disorder, the 101 most important questions and answers], Hachinger Verlagsgesellschaft

Dr Siegbert Tempelhof, 1st edition 2017, Krankheitsursache Atlaswirbel, Beschwerden heilen, die Arzte ratios machen [First cervical vertebra causes illness, healing symptoms which baffle doctors], Arkana Verlag